QUINOLONE TOXICITY SUPPORT UK

Links and Resources

 

Yellow Cards

 

It's very important that you report your Adverse Reactions to MHRA (Medicines and Healthcare Products Regulatory Agency) via the Yellow Card Scheme.  Your doctor or pharmacist should also be advised, and they may possibly send in a Yellow Card as well.

 

 

https://yellowcard.mhra.gov.uk

 

Go to this link and follow the easy instructions.  It helps if you have the packaging with you as they ask for the batch number and dates the drugs were taken.  If you feel you can't do this yourself, ask someone to do it for you.  MHRA actively encourage patients to register any potential side effects from any drug and to update frequently if the effects continue.  If no one reports anything they'll never know there's a problem!

 

You can also email MHRA directly for information about  Quinolones such as updates to the Patient Information Leaflets (PILs), statistics of how many people have been affected etc.  We believe it's important to keep reminding them about how dangerous these drugs are, so the more emails they receive the more notice they'll have to take.

 

info@mhra.gsi.gov.uk

 

Writing to your GP

 

  With the help of a GP, we have produced a letter to show your doctor that your symptoms are not just in your head.  It's deliberately short and gives very few references so he/she should manage to read it during an appointment!  Just copy and paste into a document, add a date – and add your name if you want to, then print!

 

MHRA figures show Ciprofloxacin has seriously affected thousands of people in the UK.

 

Dear Doctor,

 

Ciprofloxacin remains a popular drug of choice for GPs despite constant rumblings about tendon rupture and a long list of possible side effects.  Media stories may be ignored but a patient in your surgery with all-over excruciating pain, crushing headache, insomnia and psychiatric disturbance might pose a problem, especially if it's been a couple of weeks – or months – since you prescribed the antibiotic.  The MHRA have recently stated that up to August 31st 2017 there have been 8591 ADR reports and 165 deaths linked to Ciprofloxacin and the other Quinolones since the Yellow Card system began.  They also revealed that only 10-15% of serious ADRs are reported, which suggests that these UK figures could actually be nearer to 80,000 patients with severe problems and maybe 1200 deaths.  Many sufferers are diagnosed with Fibromyalgia, CFS, ME, MS or psychiatric problems so the causal link would not be made.

 

While the BNF lists the side effects, it fails to mention that these are actually Adverse Reactions, which can often be long-term disabling or even permanent (e.g. peripheral neuropathy).  It's also never recognised that the toxicity is cumulative, with patients successfully taking one or more courses of these drugs until their tolerance threshold is reached (1), nor that the reactions rarely present as a single symptom, and can appear in any combination at any time up to perhaps 12 months after cessation of the drug (2).

 

On the 26th July 2016, the FDA issued an update which enhances their earlier warnings about Fluoroquinolones' “association with disabling and potentially permanent side effects”, and point out that “These side effects can occur hours to weeks after exposure”, adding “It’s important that both health care providers and patients are aware of both the risks and benefits of fluoroquinolones and make an informed decision about their use”(3).

 

There are many academic papers regarding Quinolones, two of which were published by the BMJ in 2015: “Fluoroquinolones and collagen associated severe adverse events” which concluded that Quinolones are associated with subsequent tendon rupture and may also contribute to aortic aneurysms (4). Also “Fluoroquinolone induced serious, persistent, multisymptom adverse effects”(2).  A new paper, published in September 2017 titled “Treatment of the Fluoroquinolone Associated Disability, the pathobiochemical implications”, is the first paper to look at the many ways Quinolones create chaos at molecular level as well as discussing possible treatments (5).  Other studies focus on (e.g.) damage to Mitochondrial DNA, crossing of the blood-brain barrier, and the discovery that Ciprofloxacin is no better than a placebo for most chronic prostatitis/CPPS.  In the light of these, and the FDA update, I am currently discussing with MHRA about strengthening the PIL warnings and have founded the group Quinolone Toxicity Support UK to help and provide information to sufferers in the UK .

 

Thank you,

 

Miriam Knight

Quinolone Toxicity Support UK

 

quintoxuk@btinternet.com

www.quintoxsupport.co.uk 

 

1. http://www.ncbi.nlm.nih.gov/pmc/articles/PMC2895369/?report=classic Mechanisms of Pathogenesis in Drug Hepatotoxicity Putting the Stress on Mitochondria. Jones et al. April 2010

2. http://www.myquinstory.info/wp-content/uploads/2015/10/FQ-induced-serious-persistent-multisx-adverse-effects-BMJ-Case-Reports.pdf               Golomb et al.

3. http://www.fda.gov/NewsEvents/Newsroom/PressAnnouncements/ucm513183.htm

4. http://bmjopen.bmj.com/content/5/11/e010077.full        Daneman et al.

5. https://www.hindawi.com/journals/omcl/aip/8023935/  Michalak et al

 

 

 

 

 

MHRA and the FDA

 

These links are to past MHRA Drug Safety Updates (DSUs) followed by the US Food and Drug Administration (FDA) alerts to show just how far behind we are with regard to warnings about Quinolones.

 

MHRA

https://www.gov.uk/drug-safety-update/levofloxacin-some-indications-restricted  (from Sept 2012)

https://www.gov.uk/drug-safety-update/moxifloxacin-increased-risk-of-life-threatening-liver-reactions-and-other-serious-risks       (from Jan 2011)

https://www.gov.uk/drug-safety-update/norfloxacin-restricted-use-in-urinary-infections   (from Dec 2008)

http://webarchive.nationalarchives.gov.uk/20090511015115/http://mhra.gov.uk/home/idcplg?IdcService=GET_FILE&dDocName=CON023077&RevisionSelectionMethod=LatestReleased   (from 2008 re Moxifloxacin - page 8)

 

 

FDA

 

The latest FDA Update concerning Quinolones was issued on July 26th  2016.

http://www.fda.gov/NewsEvents/Newsroom/PressAnnouncements/ucm513183.htm

 

or the full pdf can be read here – but it's 69 pages long!

http://www.accessdata.fda.gov/drugsatfda_docs/label/2016/020634s067,020635s073,021721s034lbl.pdf)

 

The main points here are taken from the summary in the press announcement:

 

“It’s important that both health care providers and patients are aware of both the risks and benefits of fluoroquinolones and make an informed decision about their use.”

 

“...fluroquinolones are associated with disabling side effects involving tendons, muscles, joints, nerves and the central nervous system. These side effects can occur hours to weeks after exposure to fluoroquinolones and may potentially be permanent.”

 

“Because the risk of these serious side effects generally outweighs the benefits for patients with acute bacterial sinusitis, acute exacerbation of chronic bronchitis and uncomplicated urinary tract infections, the FDA has determined that fluoroquinolones should be reserved for use in patients with these conditions who have no alternative treatment options. For some serious bacterial infections, including anthrax, plague and bacterial pneumonia among others, the benefits of fluoroquinolones outweigh the risks and it is appropriate for them to remain available as a therapeutic option.”

 

As I write this the 2016 US Presidential Race between Hillary Clinton and Donald Trump is picking up speed.  Two days ago (14th Sept 2016) it was revealed that Mrs Clinton had just been prescribed a 10 day course of Levoquin (Levofloxacin) for mild pneumonia.

(http://www.usatoday.com).  This is one of the illnesses the FDA just said it shouldn't be used for!

 

 

http://www.fda.gov/Drugs/DrugSafety/ucm500143.htm             This update from the FDA was issued on the 12th May 2016 as a pre-cursor to the July announcement, and says much the same. It comprehensively covers ALL Quinolone antibiotics and states:

 

“The U.S. Food and Drug Administration is advising that the serious side effects associated with fluoroquinolone antibacterial drugs generally outweigh the benefits for patients with sinusitis, bronchitis, and uncomplicated urinary tract infections who have other treatment options.  For patients with these conditions, fluoroquinolones should be reserved for those who do not have alternative treatment options.”

 

http://www.fda.gov/downloads/Drugs/DrugSafety/UCM365078.pdf     This one from August 2013 required ALL Quinolone packaging (except eye and ear drops) to carry warnings of the “serious side effect of of peripheral neuropathy” which may become permanent.

http://www.fda.gov/Drugs/DrugSafety/PostmarketDrugSafetyInformationforPatientsandProviders/ucm126085.htm         The FDA issued this alert in July 2008 advising manufacturers of Quinolones to add a Boxed Warning (known as a Black Box) to highlight the dangers of the increased risk of developing tendinitis and tendon rupture with taking these drugs.

 

The BMJ

 

The British Medical Journal is one of the World's oldest yet highest-ranking medical journals so we were delighted when they published two papers about Quinolones in September 2015.

 

http://bmjopen.bmj.com/content/5/11/e010077.full.pdf       which concludes that Quinolones are associated with subsequent tendon ruptures and may also contribute to aortic aneurysms.

 

http://www.myquinstory.info/wp-content/uploads/2015/10/FQ-induced-serious-persistent-multisx-adverse-effects-BMJ-Case-Reports.pdf      which demonstrates that Quinolones cause persistent  multisymptom  Adverse Effects

 

http://www.bmj.com/content/bmj/324/7349/1306.full.pdf    this third paper was published in 2002 and demonstrates a link between Quinolones and tendinitis, especially in those over 60.  An increased risk was seen if corticosteroids were taken at the same time

 

Other journals

 

http://natajournals.org/doi/pdf/10.4085/1062-6050-49.2.09      This is a useful paper published in the Journal of Athletic Training in June 2014, which outlines the dangers of applying normal sports injury techniques to Quinolone damaged tendons.

 

http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3175508/pdf/bcp0072-0381.pdf    The British Journal of Clinical Pharmocology published this article in 2011, describing the neurotoxic effects of the different groups of antibiotics.  Scroll down 4 pages to see Table 2, and Quinolones are discussed at the bottom of that page.

 

 

Daily Mail Articles

 

The Daily Mail have featured Quinolones quite a few times over the years, the first article being published in May 2016 after we contacted them!

 

http://www.dailymail.co.uk/health/article-3593515/Antibiotics-got-rid-chest-infection-Jane-says-destroyed-health.html  2016

 

http://www.dailymail.co.uk/health/article-2097415/Taking-antibiotics-ruptured-tendon-The-hidden-dangers-everyday-drugs-assume-harmless.html    2012

 

http://www.dailymail.co.uk/health/article-3451468/Common-antibiotics-trigger-DELIRIUM-Drugs-cause-confusion-hallucinations-agitation-weeks-study-warns.html   2016

 

 

Other Articles

 

http://www.theecologist.org/News/news_analysis/897407/popular_antibiotic_ciprofloxacin_linked_to_uk_deaths.html  published in 2011 – nothing's changed.

 

http://www.theguardian.com/commentisfree/2012/jul/10/growing-menace-adverse-drug-reactions  2012  - the journalist himself had a brief episode of being floxed.

 

 

http://www.iflscience.com/health-and-medicine/just-one-antibiotic-treatment-can-alter-your-gut-microbiome-months/  published in November 2015, this paper shows how antibiotics disrupt your gut – for up to 12 months in the case of Ciprofloxacin!  For the less colourful but full academic paper go to     http://mbio.asm.org/content/6/6/e01693-15.full

 

 

http://www.ph.ucla.edu/epi/bioter/newciprosameeffects.html

Published as 'New Cipro, Same Side Effects' in the Washington Post December 2002, this article discusses the introduction of Cipro XL, the one a day tablet.  It also usefully mentions the 2000 postal workers from North East Washington who were put on a 60 day course of Cipro after 2 colleagues died from anthrax exposure the previous year.

 

https://www.washingtonpost.com/national/health-science/it-pays-to-read-the-warnings-when-you-open-up-a-prescription/2015/08/03/a29e11b4-d70e-11e4-b3f2-607bd612aeac_story.html

Another Washington Post story, and very informative.

 

One of our members is bravely writing a blog about his life, his symptoms and his ups and downs.  You may like to read it to see what happens, to sympathise, or to just say you never knew!

https://chriscwharris.wordpress.com

 

 

There are links to over 200 academic papers and media articles on the Floxie Hope website at https://floxiehope.com/  plus many articles written by Lisa Bloomquist herself.

 

 

 

 

Art by Debbie Carol